Which of the following enzymes is responsible for relieving the supercoiling tension that arises during DNA replication?
DNA polymerase
DNA ligase
Helicase
Topoisomerase
Topoisomerase is responsible for relieving the supercoiling tension that arises during DNA replication. DNA polymerase is responsible for synthesizing new DNA strands, DNA ligase is responsible for joining the Okazaki fragments on the lagging strand, and helicase is responsible for unwinding the double-stranded DNA.
Option 4 is the correct answer.