2. Explain the autoregulatory mechanism of GFR.

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S Sonika

The kidneys have built-in mechanisms for the regulation of glomerular filtration rate. One such mechanism is the Juxtaglomerular apparatus. Juxtaglomerular apparatus is a microscopic structure located between the vascular pole of the renal corpuscle and the returning distal convoluted tubule of the same nephron. It plays a role in regulating the renal blood flow and glomerular filtration rate. When there is a fall in the glomerular filtration rate, it activates the juxtaglomerular cells to release renin. This stimulates the glomerular blood flow, thereby bringing the GFR back to normal. Renin brings the GFR back to normal by the activation of the renin-angiotensin mechanism.

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