How are prosthetic groups different from co-factors?

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Solution:

Enzymes are made up of a single or multiple polypeptide chains. But in several cases,there are non-protein constituents that are bound to the enzyme, they are known as co-factors, which makes the enzyme catalytically active. Co-factors can be of three types, i.e. enzymes, prosthetic groups, and metal ions.
Co-factors and prosthetic groups differ in the sense that prosthetic groups are tightly bound to the apoenzyme.

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