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It is said that the harmful alleles get eliminated from the population over some time, yet sickle cell anaemia is persisting in the human population. Why?
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A single pair of allele, i.e. HbA and HbS, controls the sickle cell anaemia. The offspring may suffer from this disease if both parents are heterozygous (HbAHbS). But the offspring should be homozygous (HbSHbS) because heterozygous carry this disease. However, it still persists in humans because, in adaptation, heterozygous individuals are advantageous.
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