Based on the doctor's advice regarding the blood groups of the couple, which combination is most likely to result in a situation where they should not have more than one child?
Male Rh+ and Female Rh-
Female Rh+ and Male Rh-
Male Rh- and Female Rh+
Male Rh- and Female Rh-
If the male has Rh+ blood and the female has Rh- blood, it is most likely that the couple should not have more than one child based on the doctor's advice. This is because Rh incompatibility can arise in such a situation, especially during pregnancy. If the fetus inherits the Rh+ factor from the father, it may lead to complications in subsequent pregnancies, potentially causing harm to the fetus's red blood cells. To avoid these risks, it is generally recommended to limit family size or seek appropriate medical interventions.
Hence, the correct answer is option 1.