Considering the partial denaturation of the active site of enzyme E, which catalyzes reaction X, which of the following quantities associated with reaction X is most susceptible to alteration compared to the native form of enzyme E?
The rate constant k
The Boltzmann constant kB
The heat of reaction ΔH
The equilibrium constant Keq
The rate constant (k) is most likely to be affected by the partial denaturation of the enzyme's active site compared to the native form of the enzyme. The rate constant represents the speed at which the reaction X proceeds and it is influenced by the active site's conformation and functionality. Partial denaturation can disrupt the active site's structure and impair its ability to bind and catalyze the reaction, resulting in changes in the rate constant. Therefore, option 1 is the correct answer.