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During absolute refractory period
Option: 1
one-way direction of an impulse from the cell body to the axon terminal is ensured
Option: 2
another stimulus given to the neuron (no matter how strong) will not lead to a second action potential.
Option: 3
a stronger than normal stimulus is needed in order to elicit an action potential
Option: 4
channels begin to recover from inactivation
Answers (1)
As we have learnt in Refractory Periods:
- At the peak of the action potential, all Na+ channels become inactivated.
- When Na+ channels are inactivated, they cannot be immediately opened again.
- Recovery from inactivation is a time- and voltage-dependent process and full recovery usually take about 3-4 ms.
- Therefore, it takes about 3-4 ms for all Na+ channels to come out of inactivation in order to be ready for activation (opening) again.
- The period from the initiation of the action potential to immediately after the peak is referred to as the absolute refractory period (ARP).
- This is the time during which another stimulus given to the neuron (no matter how strong) will not lead to a second action potential.
- Thus, because Na+ channels are inactivated during this time, additional depolarizing stimuli do not lead to new action potentials.
- The absolute refractory period takes about 1-2 ms.
Therefore, during absolute refractory period, another stimulus given to the neuron (no matter how strong) will not lead to a second action potential. Hence, the correct answer is option b.
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