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Identify the option that represents a typical instance of 'feedback inhibition':

 

 

Option: 1

 The reaction between Cyanide and cytochrome.


Option: 2

The interaction between sulpha drugs and bacteria involved in Folic acid synthesis.


Option: 3

Allosteric inhibition of Hexokinase by Glucose 6-phosphate.

 


Option: 4

The reaction involves Succinic dehydrogenase and Succinic acid.


Answers (1)

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Feedback inhibition is a regulatory mechanism in which the end product of a metabolic pathway inhibits an earlier step in the pathway, thereby regulating its own production. In this case, the inhibition of Hexokinase, an enzyme involved in glucose metabolism, by its product Glucose 6-phosphate is an example of feedback inhibition.

Glucose 6-phosphate acts as an allosteric inhibitor, binding to a regulatory site on Hexokinase and altering its shape and activity, thereby reducing its enzymatic activity. This regulation helps to maintain appropriate levels of glucose metabolism and prevent the accumulation of excessive glucose 6-phosphate.Hence,the correct answer is option 3.

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Irshad Anwar

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