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In the scenario where the secretion of parietal cells of gastric glands is inhibited by an inhibitor, which of the following consequences is likely to occur?

Option: 1

The release of enterokinase from the duodenal mucosa will be hindered, resulting in the absence of trypsinogen conversion into trypsin.


Option: 2

Chymosin will be inadequately present in gastric juice.


Option: 3

Pepsinogen levels in gastric juice will be insufficient.


Option: 4

Without the secretion of HCl, the conversion of inactive pepsinogen into active pepsin will not take place.


Answers (1)

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Option 4 is the correct answer because if the secretion of parietal cells in the gastric glands is blocked, HCl production is reduced. Without sufficient HCl, pepsinogen cannot be converted into its active form, pepsin. As a result, the digestion of proteins in the stomach is compromised. This demonstrates the importance of HCl secretion in the activation of pepsinogen and the subsequent digestion of proteins.

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Irshad Anwar

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