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Pyruvate dehydrogenase is subject to feedback inhibition by its products in glycolysis. Some of the chemical compounds which might be involved in the process are listed below:
P. NADH
Q. FAD
R. Acetyl-CoA
S. Acetaldehyde
Which one of the following combinations of the above chemical compounds are involved in the feedback inhibition of pyruvate dehydrogenase?
P and Q
Q and R
R and S
P and R
Answers (1)
The chemical compounds that might be involved in the feedback inhibition of pyruvate dehydrogenase in glycolysis are:
Acetyl-CoA: High levels of acetyl-CoA, the product of the pyruvate dehydrogenase reaction, can inhibit the activity of pyruvate dehydrogenase. Acetyl-CoA functions as an allosteric inhibitor, regulating the activity of the enzyme.
NADH: Elevated levels of NADH, which is produced during the conversion of NAD+ to NADH in glycolysis and the citric acid cycle, can also inhibit pyruvate dehydrogenase. NADH acts as an allosteric inhibitor, negatively regulating the enzyme.
Both acetyl-CoA and NADH serve as indicators of high energy and metabolic intermediates in the cell. When these compounds accumulate, it signals that there is an excess of energy or metabolic intermediates in the cell, and further production needs to be slowed down. Thus, the feedback inhibits pyruvate dehydrogenase to control the rate of glucose metabolism and maintain metabolic balance. Hence, the correct answer is option 4.
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