Some hormones can act on their target cells through second messengers. Identify the one that does not act on their target cells through second messengers.
Cortisol
Adrenaline
FSH
Calcitonin
The hormone that does not act on its target cells through second messengers is cortisol.Cortisol belongs to a class of hormones called steroid hormones, which are lipid-soluble and can easily cross cell membranes. Once inside a target cell, cortisol binds to intracellular receptors, and the hormone-receptor complex directly alters gene expression, without the need for a second messenger system. Hence, the answer is option 1.