Which combination of relative values of km (Michaelis constant) and kcat (catalytic rate constant) would indicate a high catalytic efficiency for an enzyme?
Low km and low kcat
High km and high kcat
High km and low kcat
Low km and high kcat
The combination of low km (Michaelis constant) and high kcat (catalytic rate constant) indicates a high catalytic efficiency for an enzyme.
A low km value indicates that the enzyme has a high affinity for its substrate, meaning it can effectively bind to the substrate at relatively low concentrations.
On the other hand, a high kcat value indicates that the enzyme has a high turnover rate, meaning it can efficiently convert substrate molecules into product molecules per unit time.
Hence, the correct answer is option 4.