Which of the following hormones can activate both G protein-coupled receptors and intracellular receptors?
Epinephrine
Aldosterone
Prolactin
Follicle-stimulating hormone
Epinephrine (also known as Adrenaline) can activate both G protein-coupled receptors (GPCRs) and intracellular receptors. When epinephrine binds to GPCRs on the cell membrane, it activates the G protein, which then triggers the production of the secondary messenger cAMP, leading to various cellular responses. Epinephrine can also cross the cell membrane and bind to intracellular receptors, such as the nuclear receptor family, which regulates gene expression. Hence, the correct answer is option 1.