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Which of the following model suggests for modification of active sites by substrate?
Option: 1
Lock and Key Model
Option: 2
Induced Fit Model
Option: 3
Substrate Model
Option: 4
All of these
Answers (1)
Models:
- The active site and the substrate bind via non-covalent bonds.
- In order for these bonds to be functional, the distance between the active sites and substrate should be minimal.
- It implies that the substrate must fit in the active sites.
- Lock and Key Model: It was put forward by Emil Fischer in 1894. It suggests that the substrate fit into an active site like a key fits into the lock, all because of exact complementary shapes.
- Induced Fit Model: It is the modification of lock and key hypothesis which was proposed by Koshland in 1959. It suggests that the shape of the active site becomes complementary to the substrate when the substrate binds to the active site.
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