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Which one of the following enzymes is not a part of the pyruvate dehydrogenase enzyme complex in the glycolysis pathway?
Pyruvate dehydrogenase
Dihydrolipoyl transferase
Dihydrolipoyl dehydrogenase
Dihydrolipoyl oxidase
Answers (1)
The enzyme "Dihydrolipoyl oxidase" is not a part of the pyruvate dehydrogenase enzyme complex in the glycolysis pathway.
The pyruvate dehydrogenase enzyme complex is responsible for catalyzing the conversion of pyruvate, a product of glycolysis, into acetyl-CoA, which is further utilized in the citric acid cycle (also known as the Krebs cycle or TCA cycle). The complex consists of three core enzyme components:
Pyruvate dehydrogenase (E1): This enzyme catalyzes the decarboxylation of pyruvate, forming a hydroxyethyl-TPP intermediate.
Dihydrolipoyl transacetylase (E2): This enzyme transfers the acetyl group from the hydroxyethyl-TPP intermediate to coenzyme A (CoA), forming acetyl-CoA. It also regenerates the oxidized form of the lipoyl group.
Dihydrolipoyl dehydrogenase (E3): This enzyme catalyzes the regeneration of the oxidized form of the lipoyl group by transferring electrons to NAD+, producing NADH.
Dihydrolipoyl oxidase is not a component of the pyruvate dehydrogenase enzyme complex. It is not involved in the conversion of pyruvate to acetyl-CoA. The function of dihydrolipoyl oxidase is to regenerate the oxidized form of the lipoyl group in the complex, which is necessary for the continued activity of the E2 component.
Therefore, dihydrolipoyl oxidase is not a part of the pyruvate dehydrogenase enzyme complex in the glycolysis pathway. Hence, the correct answer is option 4.
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