The biggest constraint of plant breeding is:
a. availability of desirable genes in the crop and its wild relatives
b. infrastructure
c. trained manpower
d. transfer of genes from unrelated sources.
The constraint of plant breeding is that the desirable genes, such as disease resistance genes, drought resistance genes, etc., in a plant crop are often unavailable in the cultivated crop varieties or their wild relatives.
Hence, the answer is option (a) availability of desirable genes in the crop and its wild relatives.